Papers (since 2005)

1. Simi Gunaseelan, Shahriar Pooyan, Peiming Chen, Mahta Samizadeh, Matthew S. Palombo, Stanley Stein, Xiaoping Zhang, and Patrick J. Sinko, Multimeric peptide-based PEG nanocarriers with programmable elimination properties, Biomaterials, 30: 5649-5659 (2009).

2. SivaNaga S. Anumolu, Yashveer Singh, Dayuan Gao, Stanley Stein, and Patrick J. Sinko, Design and evaluation of novel fast forming pilocarpine-loaded hydrogels for sustained pharmacological response, Journal of Controlled Release, 137: 152-159 (2009).

3. Xiaoping Zhang, Yongjiu Jin, Mark R. Plummer, Shahriar Pooyan, Simi Gunaseelan, and Patrick J. Sinko, Endocytosis and membrane potential are required for HeLa cell uptake of R.I.-CKTat9, a retroinverso Tat cell penetrating peptide, Molecular Pharmaceutics, 6: 836-848 (2009).

4. Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, and Patrick Sinko, "Non-enzymatic, Self-Elimination Degradation Mechanism of Glutathione", Chemistry and Biodiversity, 6: 527-539 (2009).

5. Matthew S. Palombo, Yashveer Singh, and Patrick J. Sinko, "Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy", Journal of Drug Delivery Science and Technology, 19: 3-14 (2009).

6. Yashveer Singh, Matthew Palombo, and Patrick J. Sinko, “Recent Trends in Targeted Anticancer Prodrug and Conjugate Design, Current Medicinal Chemistry 15: 1802 - 1826 (2008).

7. Helen H. Usansky and Patrick J. Sinko,“Differential Roles of Pgp, Mrp2 and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats”, Drug Metabolism and Disposition, 36: 1802-1826 (2008).

8. Li Wan, Xaioping Zhang, Shahriar Pooyan, Matthew S. Palombo, Michael J. Leibowitz, Stanley Stein and Patrick J. Sinko, “Optimizing Size and Copy Number for Peg-Fmlf (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarrier Uptake by Macrophages”, Bioconjugate Chemistry, 19 (1): 28-38 (2008).

9. Anthony R. Vortherms, Robert P. Doyle, Dayuan Gao, Olivia Debrah, and Patrick J. Sinko, “Synthesis, Characterization, And In Vitro Assay Of Folic Acid Conjugates Of 3´-Azido-3´-Deoxythymidine (Azt): Toward Targeted Azt Based Anticancer Therapeutics”, Nucleosides, Nucleotides, and Nucleic Acids, 27:1–13 (2008).

10. Yaming Su, P. Hu, Sung-hack Lee, Patrick J. Sinko, “Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan”, Journal of Pharmacy and Pharmaceutical Sciences, 10 (4): 519-536 (2007).

11. Li Wan, Shahriar Pooyan, Peidi Hu, Michael J. Leibowitz, Stanley Stein, and Patrick J. Sinko,  “Peritoneal Macrophage Uptake, Pharmacokinetics and Biodistribution of Macrophage-Targeted PEG-fMLF (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarriers for Improving HIV Drug Delivery” Pharmaceutical Research, 24 (11): 2110-2119 (2007).

12. Yaming Su, Xiaoping Zhang, Patrick J. Sinko, “Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: A promising new approach to the treatment of multidrug resistant cancer”, Cancer Letters, 253 (1) 115-123 (2007).

13. Yaming Su, Ziaoping Zhang, Sung-Hack Lee and Patrick J. Sinko, “Inhibition Of Efflux Transporter ABCG2/BCRP Does Not Restore Mitoxantrone Sensitivity In Irinotecan-Selected Human Leukemia CPT-K5 Cells”, European Journal of Pharmaceutical Sciences, 29 (2): 102-110 (2006).

14. Anita Lalloo, Piyun Chao, Peidi Hu, Stanley Stein and Patrick Sinko “Pharmacokinetic And Pharmacodynamic Evaluation Of A Novel In Situ Forming Poly(Ethylene Glycol)-Based Hydrogel For The Controlled Delivery Of The Camptothecins”, Journal Of Controlled Release, 112 (3): 333-342 (2006).

15. Yaming Su and Patrick J. Sinko, “Drug Delivery Across the Blood-Brain-Barrier: Why Is It Difficult? How to Measure and Improve It?”, Expert Opinion on Drug Delivery, 3 (3): 419-435 (2006).

16. J. Polli and P. Sinko, “Preface”, Theme issue - Drug Transporters: Integration in Understanding ADME, European Journal of Pharmaceutical Sciences, 27 (5): 391, 2006.

17. S.H. Lee and P. J. Sinko, “siRNA – Getting the message out”, Theme issue - Drug Transporters: Integration in Understanding ADME, European Journal of Pharmaceutical Sciences, 27 (5): 401-410 (2006).

18. Pankaj V. Paranjpe and Patrick J. Sinko, “Programmed and Tumor-Targeted Delivery of Anticancer Drugs Using Macromolecular Bioconjugates”, American Pharmaceutical Review, 1-5 (2006).

19. Li Wan, Simi Gunaseelan, Shahriar Pooyan, Olivia Debrah, Xiaoping Zhang, Michael J. Leibowitz, Arnold B. Rabson, Stanley Stein and Patrick J. Sinko, “Novel Multi-component nanopharmaceuticals derived from poly(ethylene) glycol bioconjugates, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects”, AIDS Research and Therapy, doi:10.1186/1742-6405-3-12, 3 (1) article 12 (2006).

20. Seonghee Park And Patrick J. Sinko, “The Blood-Brain Barrier Sodium-Dependent Multivitamin Transporter (Smvt): A Molecular Functional In Vitro - In Situ Correlation”, Drug Metabolism and Disposition, 33 (10): 1547–1554 (2005).

21. Rajinder K Bhardwaj, Dea Herrera-Ruiz, Patrick J. Sinko, Olafur S. Gudmundsson and Gregory Knipp, “Delineation Of hPepT1 Mediated Uptake And Transport Of Substrates With Varying Transporter Affinities Utilizing Stably Transfected Hpept1/Mdck Clones And Caco-2 Cells”, Journal of Pharmacology and Experimental Therapeutics, 314 (3): 1093-1100 (2005).

22. Pankaj V. Paranjpe, Stanley Stein and Patrick J. Sinko, "Tumor-Targeted and Activated Bioconjugates for Improved Camptothecin Delivery", Anti-Cancer Drugs, 16 (7): 763-775 (2005).

23. Helen H. Usansky and Patrick J. Sinko, “Estimating Human Drug Oral Absorption Kinetics From Caco-2 Permeability Using an Absorption-Disposition Model: Model Development and Evaluation and Derivation of Analytical Solutions for ka and Fa”, Journal of Pharmacology and Experimental Therapeutics, 314 (1): 391-399 (2005).

24. S.S. Dharap, Y. Wang, P.Chandna, J. J. Khandare, B. Qiu, S. Gunaseelan, P. J. Sinko, S. Stein A. Farmanfarmaian, and T. Minko, “Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide”, Proceedings of the National Academy of Science, 102 (36):12962-12967 (2005).

25. Fanfan Zhou, Wen Xu, Mei Hong, Zui Pan, Patrick J. Sinko, Jianjie Ma, and Guofeng You, “The role of N-linked glycosylation in protein folding, membrane targeting and substrate binding of human organic anion transporter hOAT4”, Molecular Pharmacology, 67 (3):868-876 (2005).

26. Seonghee Park and Patrick J. Sinko, “P-Glycoprotein And Mutlidrug Resistance Associated Proteins Limit The Brain Uptake Of Saquinavir In Mice”, Journal of Pharmacology and Experimental Therapeutics, 312 (3):1249-1256 (2005).

27. Kyoung-Jin Lee, Nikole Johnson, Jesus Castelo, Patrick J. Sinko, George Grass, Kevin Holme, and Young-Hee Lee, “Effect of Experimental pH on the Permeability in Rabbit Intestines and Caco-2 Monolayers”, European Journal of Pharmaceutical Sciences, 25 (2-3):193-200 (2005).