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NMR-based metabonomic analyses of horse serum: detection of metabolic markers of disease
S. L. Ralston, L. Pappalardo, I. Pelczer, and P. F. Spears
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NMR-based Metabonomic Analysis of Serum From Standardbred Yearlings With or Without Hock Osteochondrosis Dessicans Lesions: Preliminary Study

Metabonomic analyses use multivariate statistical cluster analyses of Nuclear Magnetic Resonance (NMR) spectra from biological samples to find metabolic markers associated with diseases^{1-4^}. The detection of significant differences in large numbers of metabolites from diseased and normal individuals can lead to the development of novel diagnostic and therapeutic modalities based on deeper understanding of the metabolic processes involved^{1-4^}. Osteochondrosis dessicans (OCD) is a developmental orthopedic disease that has been well documented to have a genetic basis in Standardbreds and other breeds ^{as quoted in 5}^ but the actual metabolic defects causing the lesions have not been well defined^{5}^. The presence of OCD lesions has been correlated with abnormal insulin sensitivity in young horses but never proven to be a true causal factor^{6, 7}^. Our overall objective was to determine if metabonomic analyses of NMR spectra of serum samples of yearling horses would detect consistent metabolic differences between yearlings that had had hock OCD versus closely related yearling raised in the same environment that did not have hock lesions.





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