Publications: 333

Research Articles: 99

Book and textbook chapter: 26

Books: 1 

Published abstract: 207

Text Book

Patrick J. Sinko (Editor), Martin’s Physical Pharmacy and Pharmaceutical Sciences Fifth Edition, Lippincott Williams and Wilkins, ISBN: 0-7817-5027-X, Baltimore MD (2006)

1. Yashveer Singh, Matthew Palombo, and Patrick J. Sinko, “Recent Trends in Targeted Anticancer Produrg and Conjugate Design, Current Medicinal Chemistry, in press June 2008

2. Helen H. Usansky and Patrick J. Sinko,“Differential Roles of Pgp, Mrp2 and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats”, Drug Metabolism and Disposition, doi:10.1124/dmd.107.017483, 2008.

3. Li Wan, Xaioping Zhang, Shahriar Pooyan, Matthew S. Palombo, Michael J. Leibowitz, Stanley Stein and Patrick J. Sinko, “Optimizing Size and Copy Number for Peg-Fmlf (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarrier Uptake by Macrophages”, Bioconjugate Chemistry, 19 (1): 28-38, 2008.

4. Anthony R. Vortherms, Robert P. Doyle, Dayuan Gao, Olivia Debrah, and Patrick J. Sinko, “Synthesis, Characterization, And In Vitro Assay Of Folic Acid Conjugates Of 3´-Azido-3´-Deoxythymidine (Azt): Toward Targeted Azt Based Anticancer Therapeutics”, Nucleosides, Nucleotides, and Nucleic Acids, 27:1–13, 2008.

5. Yaming Su, P. Hu, Sung-hack Lee, Patrick J. Sinko, “Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan”, Journal of Pharmacy and Pharmaceutical Sciences, 10 (4): 519-536, 2007.

6. Li Wan, Shahriar Pooyan, Peidi Hu, Michael J. Leibowitz, Stanley Stein, and Patrick J. Sinko,  “Peritoneal Macrophage Uptake, Pharmacokinetics and Biodistribution of Macrophage-Targeted PEG-fMLF (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarriers for Improving HIV Drug Delivery” Pharmaceutical Research, 24 (11): 2110-2119, 2007.

7. Yaming Su, Xiaoping Zhang, Patrick J. Sinko, “Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: A promising new approach to the treatment of multidrug resistant cancer”, Cancer Letters, accepted January 2007.

8. Yaming Su, Ziaoping Zhang, Sung-Hack Lee and Patrick J. Sinko, “Inhibition Of Efflux Transporter ABCG2/BCRP Does Not Restore Mitoxantrone Sensitivity In Irinotecan-Selected Human Leukemia CPT-K5 Cells”, European Journal of Pharmaceutical Sciences, 29: 102-110, 2006.

9. Anita Lalloo, Piyun Chao, Peidi Hu, Stanley Stein and Patrick Sinko “Pharmacokinetic And Pharmacodynamic Evaluation Of A Novel In Situ Forming Poly(Ethylene Glycol)-Based Hydrogel For The Controlled Delivery Of The Camptothecins”, Journal Of Controlled Release, 112: 333-342, 2006.

10. Yaming Su and Patrick J. Sinko, “Drug Delivery Across the Blood-Brain-Barrier: Why Is It Difficult? How to Measure and Improve It?”, Expert Opinion on Drug Delivery, 3: 419-435, 2006.

11. J. Polli and P. Sinko, “Preface”, Theme issue - Drug Transporters: Integration in Understanding ADME, European Journal of Pharmaceutical Sciences, 27: 391, 2006.

12. S.H. Lee and P. J. Sinko, “siRNA – Getting the message out”, Theme issue - Drug Transporters: Integration in Understanding ADME, European Journal of Pharmaceutical Sciences, 27: 401-410, 2006.

13. Pankaj V. Paranjpe and Patrick J. Sinko, “Programmed and Tumor-Targeted Delivery of Anticancer Drugs Using Macromolecular Bioconjugates”, American Pharmaceutical Review, 1-5, 2006.

14. Li Wan, Simi Gunaseelan, Shahriar Pooyan, Olivia Debrah, Xiaoping Zhang, Michael J. Leibowitz, Arnold B. Rabson, Stanley Stein and Patrick J. Sinko, “Novel Multi-component nanopharmaceuticals derived from poly(ethylene) glycol bioconjugates, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects”, AIDS Research and Therapy, doi:10.1186/1742-6405-3-12, 3:12, 2006.

15. Seonghee Park And Patrick J. Sinko, “The Blood-Brain Barrier Sodium-Dependent Multivitamin Transporter (Smvt): A Molecular Functional In Vitro - In Situ Correlation”, Drug Metabolism and Disposition, 33: 1547–1554, 2005.

16. Rajinder K Bhardwaj, Dea Herrera-Ruiz, Patrick J. Sinko, Olafur S. Gudmundsson and Gregory Knipp, “Delineation Of hPepT1 Mediated Uptake And Transport Of Substrates With Varying Transporter Affinities Utilizing Stably Transfected Hpept1/Mdck Clones And Caco-2 Cells”, Journal of Pharmacology and Experimental Therapeutics, 314: 1093-1100, 2005.

17. Pankaj V. Paranjpe, Stanley Stein and Patrick J. Sinko, "Tumor-Targeted and Activated Bioconjugates for Improved Camptothecin Delivery", Anti-Cancer Drugs, 16: 763-775, 2005.

18. Helen H. Usansky and Patrick J. Sinko, “Estimating Human Drug Oral Absorption Kinetics From Caco-2 Permeability Using an Absorption-Disposition Model: Model Development and Evaluation and Derivation of Analytical Solutions for ka and Fa”, Journal of Pharmacology and Experimental Therapeutics, 314: 391-399, 2005.

19. S.S. Dharap, Y. Wang, P.Chandna, J. J. Khandare, B. Qiu, S. Gunaseelan, P. J. Sinko, S. Stein A. Farmanfarmaian, and T. Minko, “Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide”, Proceedings of the National Academy of Science, 6:12962-12967, 2005.

20. Fanfan Zhou, Wen Xu, Mei Hong, Zui Pan, Patrick J. Sinko, Jianjie Ma, and Guofeng You, “The role of N-linked glycosylation in protein folding, membrane targeting and substrate binding of human organic anion transporter hOAT4”, Molecular Pharmacology, 67:868-876, 2005.

21. Seonghee Park and Patrick J. Sinko, “P-Glycoprotein And Mutlidrug Resistance Associated Proteins Limit The Brain Uptake Of Saquinavir In Mice”, Journal of Pharmacology and Experimental Therapeutics, 312:1249-1256, 2005.

22. Simi Gunaseelan, Olivia Debrah, Li Wan, Michael J. Leibowitz, Arnold B. Rabson, Stanley Stein and Patrick J. Sinko, “Synthesis of Poly(Ethylene Glycol) -Based Saquinavir Prodrug Conjugates and Assessment of Release and Anti-HIV-1 Bioactivity Using a Novel Protease Inhibition Assay”,  Bioconjugate Chemistry, 15: 1322-1333, 2004.

23. Kyoung-Jin Lee, Nikole Johnson, Jesus Castelo, Patrick J. Sinko, George Grass, Kevin Holme, and Young-Hee Lee, “Effect of Experimental pH on the Permeability in Rabbit Intestines and Caco-2 Monolayers”, European Journal of Pharmaceutical Sciences, 25:193-200, 2005.

24. Pankaj V. Paranjpe, Yu Chen, Vladyslav Kholodovych,William Welsh, Stanley Stein and Patrick J. Sinko, "Tumor Targeted Bioconjugate Based Delivery of Camptothecin: Design, Synthesis and In Vitro Evaluation", Journal of Controlled Release, 100: 275-292, 2004.

25. J.R. Kunta, Sung-Hack Lee, B.A. Perry, Y. H. Lee, and P.J. Sinko, “Differentiation of Gut and Hepatic First-Pass Loss of Verapamil in Intestinal and Vascular Access-Ported (IVAP) Rabbits”, Drug Metabolism and Disposition, 32: 1293-1298, 2004.

26. Guobao Zhang, Bo Qui, Barbara Perry, Denise E. Georgopoulos Michael J. Liebowitz, Patrick J. Sinko and Stanley Stein. “Bioreversible Disulfide Linkage of Thiomide Compounds to ThiolPoly (ethylene glycol): Application to UC781, an Inhibitor of HIV-1 Reverse Transcriptase”, Journal of Applied Therapeutic Research, 4: 46-53, 2004

27. Yaming Su, Sung-Hack Lee and Patrick J. Sinko, “Practical Aspects of Transporter Model Systems: A Case Study Involving Saquinavir”, Drug Metabolism Reviews, 36: 377-389, 2004.

28. Anita Lalloo, Feng R. Luo, Ailan Guo, Pankaj Paranjpe, Sung-Hack Lee, Viral Vyas, Eric Rubin, and Patrick J. Sinko. “Membrane Transport of Camptothecin is Facilitated by Human P-glycoprotein (ABCB1) and Multidrug Resistance Protein 2 (ABCC2)”, BMC Medicine, 2:16, 2004.

29. Jeevan Kunta, Helen Usansky, Barbara Perry, and Patrick J. Sinko, “Differentiation of the Gut and Hepatic First-Pass Metabolism and Secretion of Saquinavir in Ported Rabbits”, Journal of Pharmacology and Experimental Therapeutics, 310: 359-366, 2004

30. Xiaoping Zhang, Li Wan, Shahriar Pooyan, Yaming Su, Carol R., Gardner, Michael J. Leibowitz, Stanley Stein and Patrick J. Sinko, “Quantitative Assessment Of The Cell Penetrating Properties Of R.I.-Tat-9: Evidence For A Cell Type-Specific Barrier At The Plasma Membrane Of Epithelial Cells”, Molecular Pharmaceutics, 1: 145-155, 2004

31. Yaming Su, Xiaoping Zhang and Patrick J. Sinko, “Human Organic Anion Transporting Polypeptide OATP-A (SLC21A3) Acts in Concert with P-glycoprotein (Pgp) and Multidrug Resistance Protein 2 (MRP2) in the Vectorial Transport of Saquinavir in HepG2 Cells”, Molecular Pharmaceutics, 1: 49-56, 2004

32. Jeevan Kunta and Patrick J. Sinko, “Intestinal Drug Transporters: In Vivo Function and Clinical Importance”, Current Drug Metabolism, 1: 109-24, 2004.

Books, Reviews & Contributed Chapters
Patrick J. Sinko (Editor), Martin’s Physical Pharmacy and Pharmaceutical Sciences Fifth Edition, Lippincott Williams and Wilkins, ISBN: 0-7817-5027-X, Baltimore MD (2006).
Major revisions or completely new chapters in Martin authored by Sinko:
1. Chapter 1, Introduction
2. Chapter 5, Nonelectrolytes
3. Chapter 6, Solutions of Electrolytes
4. Chapter 7, Ionic Equilibria
5. Chapter 8, Electromotive Force and Oxidation-Reduction
6. Chapter 9, Buffered and Isotonic Solutions
7. Chapter 10, Solubility and Distribution Phenomena
8. Chapter 11, Complexation and Protein Binding
9. Chapter 12, Diffusion
10. Chapter 13, Drug Release and Dissolution
11. Chapter 14, Biopharmaceutics
12. Chapter 15, Chemical Kinetics and Stability
13.Chapter 18, Coarse Dispersions
14. Chapter 19, Micromeritics

15. Yaming Su and Patrick J. Sinko, Evaluation of Drug-Transporter Interactions Using in vitro Cell Models, Optimization in Drug Discovery: in Vitro Methods, Humana Press, New Jersey (2004).

16. Sung-Hack Lee, Yaming Su, Seonghee Park and Patrick J. Sinko, In Vitro Permeation Study with Bovine Brain Microvessel Endothelial Cells, Optimization in Drug Discovery: in Vitro Methods, Humana Press, New Jersey (2004).

17. Y. Lee, G. Scucci and P. J. Sinko, Non-Invasive Peptide and Protein Delivery in Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York (2000).

18. Patrick J. Sinko, Screening Acceptable Pharmacokinetic Qualities in Early Drug Discovery in Current Opinions in Drug Discovery & Development : The Chemistry of Metabolic & Toxicological Processes. D. Johnson and D. Smith, Eds. Current Drugs, Ltd, London pp. 42-48 (1999).

19. Patrick J. Sinko, “Release Rate and In vivo Dissolution Rate : Impact on IVIVC” in Scientific Foundations for Regulating Drug Product Quality, G.L. Amidon, J.R. Robinson, and R.L. Williams, eds., American Association of Pharmaceutical Scientists Press, Alexandria, VA pp.293-304 (1997).

20. Patrick Sinko and Joachim Kohn, "Polymeric Drug Delivery Systems - An Overview" in Polymer Delivery Systems. M. El-Nokaly, D. Piatt and B. Charpentier, Eds., American Chemical Society Books, Washington, D.C., 18-41 (1993).

21. Gordon L. Amidon, Patrick J. Sinko and Maureen D. Donovan, "Oral Absorption of Peptides and Peptide-type Drugs: Problems and Prospects" in: Peptides, Theoretical and Practical Approaches to Their Delivery, Capsugel Symposia Series, Capsugel Library, pp 21-26 (1992).

22. Doo-Man Oh, Patrick J. Sinko and Gordon L. Amidon, "Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds", in: "Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Modeling" D.Z. D'Argenio, Ed., Plenum Press, New York pp 3-11 (1991).

23. Gordon L. Amidon, Patrick J. Sinko, Ming Hu and Glen D. Leesman, "Absorption of Difficult Drug Molecules; Carrier-Mediated Transport of Peptides and Peptide Analogs", in: Novel Drug Delivery and its Therapeutic Application, L.F. Prescott and W.S. Nimmo, Eds., John Wiley & Sons Ltd., Great Britain (1989).

24. Gordon L. Amidon, Glen D. Leesman Patrick J. Sinko and Ming Hu, "Design of Prodrugs for Oral Drug Delivery" Proceedings of the Second International ISSX Meeting, (Kobe, Japan, May 1988) R.W. Estabrook and M.N. Cayens, Eds., Taylor & Francis Ltd., Great Britain, 1989 pp 117-124.

25. Glen D. Leesman, Patrick J. Sinko, and Gordon L. Amidon "Simulation of Oral Drug Absorption: Gastric Emptying and GI Motility Considerations" in: Pharmacokinetics - Regulatory, Industrial, and Academic Perspectives. Peter G. Welling and Francis L. Tse (editors), Marcel Dekker, Inc. (New York), 1988, Ch. 6, p. 267.

26. Patrick J. Sinko, Cefadroxil (monograph), in: Chemical Stability of Pharmaceuticals, Second Edition, K.A. Connors, G.L. Amidon, and V.J. Stella, (editors). John Wiley and Sons, Inc., New York, (1986), 295-301.

Patents

1. Patrick J. Sinko with co-inventors: G.M. Grass, G.D. Leesman, D.A. Norris, J.E. Wehrli, “Method for screening and producing compound libraries” United States Patent 6,996,473 (issued February 7, 2006).

2. Patrick J. Sinko with co-inventors: G.M. Grass, G.D. Leesman, D.A. Norris, J.E. Wehrli, “Pharmacokinetic-based drug design tool and method” United States Patent 6,647,358 (issued November 11, 2003).

3. Patrick J. Sinko with co-inventors: G.M. Grass, G.D. Leesman, D.A. Norris, J.E. Wehrli, “Pharmacokinetic-based drug design tool and method” United States Patent 6,542,858 (issued April 1 2003).

4. Patrick J. Sinko with co-inventors: M. Leibowitz, S. Stein, “A Carrier for In Vivo Delivery of a Therapeutic Agent”, United States Patent 6,617,306 (issued September 9, 2003).

5. Patrick J. Sinko with co-inventors: Mike Leibowitz, Stanley Stein, “Materials and Processes For Controlled Release of Thio-amide Moiety Containing Therapeutic Agents by Linking to Thiol-Containing Polymets”, United States Patent 6,468,522 (issued October 22, 2002).

6. Patrick J. Sinko with co-inventors: M. Leibowitz, S. Stein, “A Carrier for In Vivo Delivery of a Therapeutic Agent”, United States Patent 6,258,774 (issued July 10, 2001).

7. P.J. Sinko with co-inventors: G.L. Amidon, G.D. Leesman, "Enhancing the Bioavailability of Proteolytically Labile Therapeutic Agents", United States Patent 6,153,592 (issued 11/28/2000).